Tony and Olivier Award-winning playwright Simon Stephens’ Heisenberg: The Uncertainty Principle is a surprising and life-affirming new two-hander starring Anne-Marie Duff and Kenneth Cranham.

In this uncertain world, who can predict what brings people together? When two strangers meet by chance amidst the bustle of a crowded London train station, their lives are changed forever.

The Uncertainty Principle is one of the most famous ideas in physics. First articulated in 1927 by German physicist Werner Heisenberg, it states that it is impossible to know simultaneously the exact position and momentum of a particle – the more exactly the position is determined, the less known the momentum, and vice-versa.

Heisenberg: The Uncertainty Principle will be scored by acclaimed composer, producer and pianist Nils Frahm, one of the most talked-about musicians of his generation.

Reuniting much of the creative team behind the National Theatre’s hugely successful productions of The Curious Incident of the Dog in the Night-Time and War Horse, Olivier and Tony Award-winning director Marianne Elliott leads the first production of her and producer Chris Harper’s newly formed theatre company, Elliott & Harper Productions. Elliott was an associate director of the National Theatre for 10 years and was the first woman in Broadway history to win two Tony Awards for Best Director.

The show features BAFTA and Olivier nominee Anne-Marie Duff as Georgie, who played the title role in Marianne’s production of Saint Joan for the National Theatre, and more recently in the highly-acclaimed NT/Royal Exchange Theatre production of Husbands and Sons, also directed by Elliott. Kenneth Cranham, known for his film, television and stage work, stars alongside Duff in the role of Alex. Cranham won the 2016 Best Actor Olivier Award for his role in Florian Zeller’s The Father.

Simon Stephens’ play first opened off-Broadway in June 2015, before transferring to Broadway’s Samuel J. Friedman Theatre, opening on 13 October 2016.

Now it arrives in the West End, where it is sure to astound and uplift in equal measure.

Dramas have a rich history in the West End; find out more about plays in London.